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Title   골 육종 및 유잉 육종에서 자가골수이식을 이용한 고용량 항암화학요법 ( High - dose Chemotherapy Followed by Autologous Bone Marrow Transplantation in High - risk Osteosarcoma and Ewing's Sarcoma )
Publicationinfo   1995 Jan; 027(03): 475-482.
Key_word   Sarcoma, Auto1ogous bone marrow transplantation
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Abstract   Purpose: The poor histologic response to standard chemotherapy, a large tumor mass(more than 10 cm) at the time of the initial diagnosis, and tumors in axial bones are the risk factors for the relapse in sarcomas with preoperative and/or postoperative standard chemotherapy and curative surgery. Ta overcome these problems, high-dose chemotherapy and stem cell rescue with autologous bone marrow transplantation were done in four osteogenic and Ewings sarcomas. Methods: Bone-marrow harvest, cryopreservation and CFU-GM assay were done as described previously. As a high-dose chemotherapy, melphalan(160 mg/m) or ifosfamide(7,500 mg2/m)+etoposide(600mg/m) + carboplatin(600 mg/m(2)) were used. Bone marrow infusion and supportive cares were followed until the hematalogic recovery. Results: 1) The number of infused mononuclear cells and CFU-GM colonies were 0.8-2.9 x 10(8)/kg and 0.1-1.2 x 10(4)/kg, respectively. 2) The duration of absolute neutropenia(<500/mm(3)) and thrombocytopenia(<50,000/mm(3)) were 8-23 days and 0-25 days, respectively. 3) All but one had febrile neutropenia for 2 7 days due to sepsis and pneumonia. There waa no therapy associated death. 4) All patients had complete response and the duration of disease free survival was 5(+)-51(+) months. Of the four patients in complete response, one subsequently relapsed in scalp l0 months after transplantation and died 6 months later due to progression of disease. Conclasion: It seems that high-dose chemotherapy with atologous bone marrow transplantation is feasible in high-risk osteosarcoma and Ewing's sarcoma and the responsiveness to chemotherapy may be the most important factor to predict the prognosis.
저 자   한지연(Ji Youn Han),문한림(Han Lim Moon),김동욱(Dong Wook Kim),이종욱(Jong Wook Lee),진종률(Jong Youl Jin),한치화(Chi Wha Han),민우성(Woo Sung Min),박종원(Chong Won Park),김춘추(Choon Choo Kim),김동집(Dong Jip Kim),김학기(Hak Ki Kim),우영균(Young Gyun Woo),김정만(Jung Man Kim)